The Absolute Best Pizza in Little Italy, San Diego: Must-Try Pies

As a San Diego native, I’ve wandered the charming streets of Little Italy, savoring every slice and crust this vibrant neighborhood offers. Pizza here isn’t just food; it’s a cultural experience, blending authentic Italian roots with California flair.

Whether you’re a local craving a quick bite or a tourist exploring our culinary scene, my toplist of the best pizza in Little Italy, San Diego guides you to unforgettable flavors. From wood-fired Neapolitan pies to hearty New York-style slices, each restaurant I’ve reviewed delivers bold tastes, fresh ingredients, and welcoming vibes. Expect cozy trattorias, trendy halls, and family-owned gems, all crafted with passion. Join me on this delicious journey to uncover Little Italy’s pizza treasures, where every bite tells a story of tradition and creativity.

Top 10 Best Pizza Restaurants in Little Italy, San Diego

As a San Diego native, I’ve explored every corner of Little Italy’s vibrant food scene, and its pizza offerings are a true standout. From wood-fired Neapolitan masterpieces to New York-style slices, these 10 restaurants deliver unforgettable flavors. Below, I share my personal experiences, complete with essential details, highlights, and honest reviews to guide locals and tourists alike to the best pizza in Little Italy, San Diego.

Landini’s Pizzeria

Address: 1827 India St, San Diego, CA 92101
Phone: (619) 238-3502
Website: landinispizzeria.com
Hours: Open from 11 AM to 1 AM daily

Highlights:

Authentic New York-style slices with a perfect crust
Vegan and vegetarian options for diverse diets
Late-night service until 1 AM on weekends
Fresh, hand-selected ingredients for vibrant flavors
Family-owned vibe with welcoming service

What makes a pizza slice worth standing in line for? Stepping into Landini’s Pizzeria, ranked #1 on my best pizza in Little Italy, San Diego toplist, I’m greeted by a lively, nostalgic atmosphere, with the aroma of fresh dough and sizzling toppings. The counter buzzes with energy, and the open kitchen feels like a slice of New York. The thin, crispy crust and bold sauce instantly win me over, making every bite a delight.

The pizza here is nothing short of spectacular. I tried the classic pepperoni, where the cupping pepperoni crisps up perfectly, releasing a smoky, savory kick. For a twist, the white pesto Leonardo pie is a creamy, aromatic masterpiece, blending ricotta and mozzarella with a vibrant pesto swirl. Portions are generous, with a single slice satisfying my hunger, leaving me eager to take a whole pie home.

The garlic knots, a must-try side, are golden, buttery pillows of dough, baked to perfection with a garlicky glaze that melts in your mouth. Made with freshly minced garlic and herbs, they’re addictive, and I’m blown away by how they complement the pizza’s bold flavors. Each knot feels like a warm hug from the kitchen.

The staff at Landini’s is incredibly friendly and knowledgeable, guiding me through the menu with enthusiasm. They’re quick to accommodate my request for extra sauce, making me feel like a regular. Their attentive service elevates the casual vibe, ensuring every visit feels personal and welcoming.

For anyone craving authentic New York-style pizza in San Diego, Landini’s is a must-visit. Whether you’re a local or a tourist, the unbeatable slices, hearty portions, and stellar service make it a top pick on my best pizza in Little Italy, San Diego toplist. Stop by for a quick slice or a late-night pie you won’t be disappointed.

Isola Pizza Bar

Address: 1526 India St, San Diego, CA 92101
Phone: (619) 255-4230
Website: isolapizzabar.com
Hours: Open from 12 PM to 10 PM daily

Highlights:

Wood-fired Neapolitan pizzas with chewy crusts
Fresh mozzarella and doppio zero flour for authenticity
Charming, vine-covered ambiance for a cozy dine-in
Creative topping combinations like spicy salami
Attentive, personalized service

Can a pizza transport you to Italy? At Isola Pizza Bar, #2 on my best pizza in Little Italy, San Diego toplist, the romantic, vine-draped exterior and warm, rustic interior make me feel like I’ve stepped into a Roman trattoria. The wood-fired oven glows, promising an authentic experience.

The pizzas are flawless, with a chewy, charred crust that’s the hallmark of Neapolitan style. The Quattro Stagioni, a culinary artwork, divides its toppings ham, mushrooms, artichokes, and olives into vibrant quadrants, each bite a new flavor adventure. The Piccante, with its spicy salami and ‘nduja, delivers a fiery kick that lingers delightfully. Portions are satisfying, perfect for sharing or savoring solo.

The cauliflower steak, a surprising side, is roasted to caramelized perfection, with a nutty, tender texture that pairs beautifully with a drizzle of olive oil. Sourced from local farms, it’s a testament to Isola’s commitment to freshness, leaving me speechless with its simplicity and depth.

The staff is exceptionally warm and engaging, offering pairing suggestions and checking in with genuine care. Their thoughtful attention, like refilling my water without asking, makes the meal feel special. They’re passionate about their craft, enhancing the overall experience.

Isola is a gem for pizza lovers and travelers seeking authentic Neapolitan flavors. With unforgettable pies, fresh sides, and impeccable service, it’s a standout on my best pizza in Little Italy, San Diego toplist. Visit for a taste of Italy right in San Diego’s heart.

Mr. Moto Pizza

Address: 1906 Fern St, San Diego, CA 92102
Phone: (619) 955-8858
Website: mrmotopizza.com
Hours: Open from 11 AM to 10 PM daily

Highlights:

New York-style thin crust with a fluffy edge
Award-winning gourmet pizzas since 2016
Famous garlic knots as a crowd-pleaser
Multiple locations for easy access
Fast, friendly service for on-the-go diners

What’s the secret to a perfect pizza handle? At Mr. Moto Pizza, #3 on my best pizza in Little Italy, San Diego toplist, the bustling, modern vibe and irresistible pizza aroma draw me in instantly. The open counter and neon signs create a fun, urban feel, perfect for a quick slice.

The pizzas are phenomenal, with a thin, crisp crust and a fluffy outer edge that’s pure magic. The Buffalo Chicken, with its tangy, spicy sauce and tender chicken, is a bold crowd-pleaser. The Veggie Supreme, loaded with crisp bell peppers and mushrooms, feels like a garden on a pie. Portions are hearty, ensuring no one leaves hungry.

The garlic knots, a signature side, are soft, buttery gems, hand-tied and baked with a garlicky sheen that’s utterly addictive. Made with fresh dough, they’re a revelation, pairing perfectly with a side of marinara that I can’t stop dipping.

The staff is upbeat and efficient, handling my order with speed and a smile. They’re accommodating, happily boxing up leftovers and offering napkins galore. Their can-do attitude makes the fast-paced environment feel welcoming and stress-free.

For a gourmet New York-style experience, Mr. Moto is a top choice on my best pizza in Little Italy, San Diego toplist. Locals and visitors will love the delicious pies, generous portions, and lively service. Grab a slice or a knot you’ll be hooked.

Mona Lisa Italian Foods

Address: 2061 India St, San Diego, CA 92101

Phone: (619) 234-4893
Website: monalisaitalianfoods.com
Hours: Open from 11 AM to 9 PM daily

Highlights:

Family-owned since 1956 with timeless recipes
Customizable crust options (standard, thin, double)
Iconic Italian sausage pizza as a local favorite
Delicious deli sandwiches for variety
Cozy, nostalgic service with a personal touch

What’s the charm of a decades-old pizzeria? Walking into Mona Lisa Italian Foods, #4 on my best pizza in Little Italy, San Diego toplist, I’m enveloped by a warm, vintage ambiance, with checkered tablecloths and family photos. It feels like home, steeped in tradition.

The pizzas are outstanding, with a chewy, golden crust that’s customizable to my liking. The Italian Sausage, with its fennel-spiced, house-made sausage, is a flavor explosion, rich and satisfying. The Mona Lisa Special, piled with pepperoni, mushrooms, and olives, is a hearty masterpiece. Portions are massive, perfect for sharing with friends.

The minestrone soup, a standout side, is simmered to perfection, brimming with fresh vegetables and tender pasta in a savory broth. It’s comfort in a bowl, warming me up and leaving me amazed at its depth of flavor.

The staff is genuinely kind and attentive, treating me like family. They’re knowledgeable about the menu, suggesting pairings and checking on my table with care. Their personalized service makes every visit feel like a reunion.

Mona Lisa is a timeless gem for pizza enthusiasts and tourists. With legendary pies, comforting sides, and heartfelt service, it’s a must on my best pizza in Little Italy, San Diego toplist. Come for the pizza, stay for the nostalgia.

Napizza

Address: 1702 India St, San Diego, CA 92101
Phone: (619) 696-9555
Website: napizza.biz
Hours: Open from 11 AM to 9 PM daily

Highlights:

Crispy Roman-style pizza with 72-hour dough
Locally sourced ingredients for freshness
Light, crunchy crust for a unique texture
Vibrant, modern ambiance with open seating
Quick, courteous service for dine-in or takeout

Can a pizza crust steal the show? At Napizza, #5 on my best pizza in Little Italy, San Diego toplist, the sleek, airy dining space and enticing scent of baking dough create a modern, inviting vibe. The open kitchen showcases the craft, pulling me in.

The pizzas are exceptional, with a crisp, feather-light crust thanks to 72-hour fermentation. The Margherita, with its bright tomato sauce and creamy mozzarella, is a classic done right. The Spicy Salami, with fiery Calabrian chiles, adds a bold twist. Portions are just right, leaving room for dessert.

The bruschetta, a delightful side, is toasted to golden perfection, topped with juicy, ripe tomatoes and fragrant basil. It’s a fresh, zesty bite that leaves me speechless, elevating the meal with its simplicity.

The staff is polished and approachable, ensuring my order is spot-on. They’re quick to assist, offering extra plates for sharing and keeping the vibe relaxed. Their professionalism shines, making every visit seamless.

Napizza is a must-try for those seeking Roman-style excellence. With crisp, flavorful pizzas, fresh sides, and top-notch service, it’s a star on my best pizza in Little Italy, San Diego toplist. Stop by for a light, delicious meal.

Filippi’s Pizza Grotto

Address: 1747 India St, San Diego, CA 92101
Phone: (619) 232-5094
Website: filippispizzagrotto.com
Hours: Open from 11 AM to 10 PM daily

Highlights:

Traditional Italian family recipes since 1950
Thick, cheesy pizzas for hearty appetites
Charming grocery store vibe with Italian goods
Generous portions ideal for groups
Friendly, homey service with a smile

What’s the allure of a pizza legacy? At Filippi’s Pizza Grotto, #6 on my best pizza in Little Italy, San Diego toplist, the cozy, old-school interior, lined with Italian grocery items, feels like a nostalgic embrace. The scent of baking pizza is irresistible.

The pizzas are hearty and indulgent, with a thick, chewy crust piled high with cheese. The Pepperoni, with its crisp, spicy slices, is a comfort food dream. The Vegetarian, bursting with fresh broccoli and mushrooms, feels wholesome yet decadent. Portions are enormous, perfect for family dinners.

The garlic bread, a standout side, is toasted to crunchy perfection, slathered with buttery garlic spread. Made with house-baked bread, it’s a crowd-pleaser, leaving me in awe of its simple brilliance.

The staff is warm and dedicated, making me feel at home. They’re attentive, refilling drinks promptly and sharing stories about the family recipes. Their genuine care enhances the comforting vibe.

Filippi’s is a beloved staple for pizza lovers and visitors. With hearty, classic pies, delicious sides, and heartwarming service, it’s a highlight on my best pizza in Little Italy, San Diego toplist. Visit for a taste of tradition.

Ambrogio15

Address: 550 West Date St, San Diego, CA 92101
Phone: (619) 450-6839
Website: ambrogio15.com
Hours: Open from 12 PM to 9 PM daily

Highlights:

Milan-style paper-thin crust for a unique bite
Gourmet toppings like burrata and prosciutto
Sleek, modern ambiance at Little Italy Food Hall
Custom crust options (white, whole wheat, gluten-free)
Attentive, stylish service for a refined experience

What’s the magic of a paper-thin pizza? At Ambrogio15, #7 on my best pizza in Little Italy, San Diego toplist, the chic, open-air setting in the Little Italy Food Hall feels trendy and inviting. The aroma of gourmet toppings draws me to the counter.

The pizzas are sublime, with a wafer-thin, crispy crust that’s almost ethereal. The Burrata e Prosciutto, with its creamy burrata and salty prosciutto, is a luxurious masterpiece. The Cinque Formaggi, a cheesy symphony, melts in my mouth. Portions are perfectly balanced, ideal for a light meal.

The panzerotti, a mini calzone side, is fried to golden crispness, stuffed with melty mozzarella and tangy sauce. It’s a delightful surprise, showcasing fresh ingredients and leaving me enchanted.

The staff is polished and engaging, offering menu insights with flair. They’re quick to customize, ensuring my gluten-free request is met with care. Their sophisticated service elevates the casual setting.

Ambrogio15 is a gourmet haven for pizza aficionados. With exquisite thin-crust pies, creative sides, and elegant service, it’s a gem on my best pizza in Little Italy, San Diego toplist. Stop by for a refined pizza experience.

Little Italy Pizzeria & Pasta

Address: 4085 Pacific Hwy, San Diego, CA 92110
Phone: (619) 295-1117
Website: littleitalypizzeriapastasandiego.com
Hours: Open from 10 AM to 10 PM daily

Highlights:

Classic cheese pizza for purists
Affordable prices for budget-friendly dining
Curbside pickup for convenience
Hearty pasta dishes as a bonus
Welcoming, no-frills service

What’s the joy of a no-fuss pizza joint? At Little Italy Pizzeria & Pasta, #8 on my best pizza in Little Italy, San Diego toplist, the casual, unpretentious space feels comfortably familiar, with the scent of freshly baked pizza filling the air.

The pizzas are reliably delicious, with a golden, chewy crust and robust sauce. The Classic Cheese, with its gooey mozzarella blanket, is a timeless winner. The BBQ Chicken, with tangy sauce and caramelized onions, adds a fun twist. Portions are generous, making it a great value.

The cheesy bread, a standout side, is baked to bubbly perfection, with a rich, garlicky topping that’s pure indulgence. Made with fresh dough, it’s a showstopper, leaving me craving more.

The staff is down-to-earth and prompt, ensuring my takeout order is ready on time. They’re accommodating, tossing in extra marinara at my request. Their straightforward service keeps things easy and pleasant.

For affordable, satisfying pizza, Little Italy Pizzeria & Pasta shines on my best pizza in Little Italy, San Diego toplist. Locals and budget-conscious travelers will love the tasty pies, hearty sides, and hassle-free service. Grab a pie to go or dine in for a casual meal.

Solunto Bakery

Address: 1643 India St, San Diego, CA 92101
Phone: (619) 255-8455
Website: soluntobakery.com
Hours: Open from 11 AM to 9 PM daily

Highlights:

Neapolitan pizzas from an Italian oven
House-baked breads for authentic sides
Cozy, authentic Roma vibes in decor
Handmade gelato for dessert
Passionate, knowledgeable service

What’s the secret to a pizza that feels like Rome? At Solunto Bakery, #9 on my best pizza in Little Italy, San Diego toplist, the intimate, rustic space, with its Italian oven glow, feels like a Roman escape. The scent of fresh basil is captivating.

The pizzas are divine, with a soft, charred Neapolitan crust. The Napoletana, with anchovies and fior di latte, is a salty, umami delight. The Quatro Stagioni, with its artful topping sections, feels like a flavor journey. Portions are satisfying, ideal for a cozy meal.

The house-baked focaccia, a stellar side, is crisp yet fluffy, drizzled with fragrant olive oil and rosemary. Made with artisan dough, it’s a revelation, leaving me in awe of its texture and taste.

The staff is passionate and attentive, sharing stories about the oven’s Italian origins. They’re thoughtful, ensuring my table is comfortable and my gelato order is perfect. Their dedication makes the experience memorable.

Solunto is a hidden treasure for pizza and gelato lovers. With authentic Neapolitan pies, artisan sides, and heartfelt service, it’s a standout on my best pizza in Little Italy, San Diego toplist. Visit for a taste of Rome in San Diego.

Nolita Hall

Address: 2305 India St, San Diego, CA 92101
Phone: (619) 255-8005
Website: nolitahall.com
Hours: Open from 11 AM to 11 PM daily

Highlights:

Trendy, seasonal pizzas with bold flavors
Vibrant, upscale ambiance for social dining
Craft cocktails to pair with pizzas
Prosciutto and sausage options for meat lovers
Lively, professional service

What’s the vibe of a pizza night with flair? At Nolita Hall, #10 on my best pizza in Little Italy, San Diego toplist, the sleek, energetic space, with its modern decor and bustling bar, feels cosmopolitan and fun. The pizza oven’s glow is mesmerizing.

The pizzas are creative and bold, with a crisp, artisanal crust. The Prosciutto, with its silky, salty slices and arugula, is a sophisticated treat. The Seasonal Veggie, with roasted squash and goat cheese, is a vibrant surprise. Portions are ample, perfect for a group hangout.

The roasted beets, a unique side, are caramelized to sweet perfection, with a creamy goat cheese drizzle. Sourced from local farms, they’re a flavor explosion, leaving me impressed by their elegance.

The staff is charismatic and professional, recommending cocktails to match my pizza. They’re attentive, ensuring my group’s orders are timed perfectly. Their lively energy makes the night unforgettable.

Nolita Hall is a trendy hotspot for pizza and cocktail fans. With inventive pies, gourmet sides, and dynamic service, it’s a must on my best pizza in Little Italy, San Diego toplist. Come for a stylish, flavorful evening.

Savor Little Italy’s Pizza Perfection

My journey through Little Italy’s top 10 pizza spots reveals a tapestry of flavors, from crispy Roman crusts to cheesy, thick pies. Each restaurant, meticulously reviewed, offers unique highlights think handmade dough, gourmet toppings, and heartfelt service. These pizzerias make Little Italy a must-visit for food lovers. Whether you’re with San Diego Nav or exploring solo, my guide ensures you find the best pizza in Little Italy, San Diego. Visit these spots to taste the heart of our city’s culinary soul.